Descrizione

Sehr gutes Ex. - Oncology - Treatments and Their Limits -- Cancer - Short History and Efforts to Cure -- Historical Notes -- The "War" Against Cancer -- Paradigm and Challenges of Oncotherapies -- Limitations of Oncotherapies - The Quest for a Step Forward -- Medical Challenge of Oncotherapies -- Ethical Challenge of Oncotherapies -- The Challenge of Evaluating the Results -- Hyperthermia Results and Challenges -- Hyperthermia Approach -- Definition of Hyperthermia in Oncology -- Basic Concepts of Oncological Hyperthermia -- Technical Variations of Hyperthermia in Oncology -- Effects of Hyperthermia -- Higher Baseline Temperature -- Vascular Changes -- Cellular Membrane Changes -- Lactic Acid Formation -- ATP Depletion -- Altered DNA Replication -- Enhanced Immune Reaction -- Pain Reduction -- Selective Gain of the Heat Resistance -- Clinical Oncological Hyperthermia -- Local and Whole-Body Heating -- Hyperthermia as a Complementary Method -- Hyperthermia Successes -- Brain Tumor Treatment by Hyperthermia -- Pancreas Tumor Treatment by Hyperthermia -- Lung and Bronchus Hepatocellular Carcinoma and Metastatic Tumors of the Liver -- Colo-Rectal Tumors -- Esophagus -- Head and Neck Localizations -- Gastric Tumors -- Breast Tumors -- Other Localizations Treated by Hyperthermia Hyperthermia Challenges in Oncology -- Challenge of Selection and Focus -- The Challenge of Temperature -- Medical Challenges of Hyperthermia in Oncology -- Challenge of Quality Control and Dosimetry of Hyperthermia -- What We Expect? -- Possible Solution: Oncothermia -- Thermo-Biophysics -- Factors of Physiology Heating -- Biothermodynamics -- Energy, Heat, and Temperature -- Energy of the Chemical Bonds and Reactions -- Energy Sources and Driving Forces -- Energy and Structure -- Energetics of Malignant Cells -- "Non-Thermal" Effects - The Thermodynamic Approach -- Bioelectrodynamics -- Basic Interactions -- The Bioimpedance -- "Non-Thermal Effects" - The Electrodynamic Approach -- "Non-Thermal Effects" - Approach of Electric Currents -- Membrane Effects -- Stochastic Processes -- Noises and Signals -- Resonances -- Modulation-Demodulation -- Special Field Effects of Biosystems -- Oncothermia - A New Kind of Oncologic Hyperthermia Oncothermia Characteristics -- Electrochemotherapy (ECT) -- Concept of Oncothermia -- Pennes Equation Revised Thermal Limit Problem -- Energy Transfer Through the Body Surface -- Penetration Depth -- Arrangement of Electrodes -- Far from Equilibrium -- Energy Intake and Temperature -- Macroscopic Focusing on the Tumor -- Heating the Extra-Cellular Electrolyte -- Temperature Gradient and Heat Flow -- on the Membrane -- Changes of the Membrane Potential -- Membrane Damage by Constrained Ion -- Currents -- Effect on Cell-Cell Connections -- Oncotherm Comparison -- Oncothermia Treatment Guidelines -- Treatment Planning -- Treatment Consensus -- Complementary Applications -- Complementary to Radiotherapy -- Complementary to Chemotherapy -- Clinical Toxicity, Safety -- Oncothermia Case Reports -- Near-Eye Treatments -- Brain Cases -- Gynecology Cases -- Gastrointestinal Cases -- Pulmonary Cases -- Other Cases -- Evaluation of Oncothermia Studies -- Evaluation Conditions -- Evaluation Methods -- General Overview on a Large Patient's Pool -- Brain Studies -- Brain Safety Study (Phase I) -- Brain Efficacy Study (Phase II) -- Hungarian Brain Glioma Study -- Small Prospective, Double-Arm Brain Glioma Study -- Study of Brain Gliomas with Local Clinical Responses -- Brain Glioma Study with Relapses -- Bicentral Brain Glioma Study -- Oncothermia for Heavily Pretreated and Relapsed Brain Gliomas Study of Metastatic Brain Tumors -- Comparison of Oncothermia Brain Studies -- Pancreas Studies -- Pancreas Efficacy Study I -- Pancreas Efficacy Study II (HTT) -- Additional Historical Control to HTT Pancreas Study -- Comparison of Pancreas Efficacy Studies I and II -- Pancreas Efficacy Study III -- Pancreas Efficacy Study IV -- Other Oncothermia Pancreas Studies and Their Comparison -- Lung Studies -- Oncothermia Lung Study I -- Oncothermia Lung Study II -- Meta-Analysis of Oncothermia Lung Studies -- Comparison to Historical Control -- Liver Studies -- Study of Liver Metastases of Colo-Rectal Origin -- Study of Advanced Liver Metastases of Colo-Rectal Origin II -- Comparison Study of Treatment Lines of Colo-Rectal Liver Metastases -- Study of Platinum Derivatives with Oncothermia for Liver Metastases of Colo-Rectal Origin -- Study of Liver Metastases of Rectal Origin -- Study of Liver Metastases of Various Origins -- Study of Very Advanced Liver Metastases of Various Origins: Comparison of Complementary Therapies -- Comparison of Studies of Liver Metastases -- Gynecological (Pelvic) Cancer Study -- Ovary Study -- Uterine Corpus Cancer -- Uterine Cervix -- Comparison of Oncothermia in Pelvic Gynecology -- Breast Study -- Esophagus Study -- Esophagus Study I -- Esophagus Study II -- Stomach Study -- Colo-Rectal Studies -- Pre-Operative Oncothermia for Rectum Carcinoma -- Colo-Rectal Carcinoma Study (u.a.) ISBN 9789048194971